Dsuvia (sufentanil) is an opioid agonist.
- surgical centers.
- emergency departments.
Secondly ,for the management of acute pain severe enough to require an opioid analgesic and for which alternative treatments are inadequate.
Hence, The recommended dosage of is 30 mcg sublingually as needed with a minimum of 1 hour between doses.
Do not exceed 12 tablets in 24 hours.
The maximum cumulative daily dose of sufentanil is 360 mcg or 12 tablets (12 tablets x 30 mcg/dose).
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Adverse effects associated with the use of Dsuvia may include, but are not limited to, the following:
Mechanism of Action
In Addition, Dsuvia (sufentanil) is an opioid agonist and is relatively selective for the mu-opioid receptor, although it can bind to other opioid receptors at higher doses.
- Significant respiratory depression.
- Acute or severe bronchial asthma in an unmonitored setting or in the absence of resuscitate equipment.
- Known or suspected gastrointestinal obstruction, including paralytic ileus.
- Known hypersensitivity to sufentanil or components of DSUVIA.
Warnings and Precautions
Most importantly, Accidental ingestion or exposure to even one dose of DSUVIA, especially in children, can result in respiratory depression and death due to an overdose of sufentanil.
Certainly, DSUVIA is for use in adult patients only in a certified medically supervised healthcare setting.
Likewise, Discontinue use of DSUVIA prior to discharge or transfer from the certified medically supervised healthcare setting. DSUVIA is not for home or pediatric use.
Therefore, DSUVIA contains sufentanil, a Schedule II controlled substance. As an opioid, DSUVIA exposes users to the risks of addiction, abuse, and misuse.
Profound sedation, respiratory depression, coma, and death may result from the concomitant use of DSUVIA with benzodiazepines or other CNS depressants (e.g., non-benzodiazepine sedatives/hypnotics, anxiolytics, tranquilizers, muscle relaxants, general anesthetics, antipsychotics, other opioids, alcohol).
Because of these risks, reserve concomitant prescribing of these drugs for use in patients for whom alternative treatment options are inadequate.
Life-threatening respiratory depression in patients with chronic pulmonary disease or in elderly, cachectic and debilitated patients:
In addition, Management of respiratory depression may include close observation, supportive measures, and use of opioid antagonists, depending on the patient’s clinical status.
A potentially life-threatening condition could result from concomitant serotonergic drug administration.
Cases of adrenal insufficiency have been reported with opioid use (usually > 1 month).
Presentation and symptoms are non-specific and include nausea, vomiting, anorexia, fatigue, weakness, dizziness and low blood pressure.
Prolonged use of DSUVIA during pregnancy can result in withdrawal in the neonate, which can be life-threatening. Observe newborns for signs of neonatal opioid withdrawal syndrome and manage accordingly.
Advise pregnant women using opioids for a prolonged period of this risk and ensure that appropriate treatment will be available.
Insufficient data are available on the use of DSUVIA in patients with severe liver or kidney impairment.
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